Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53.
Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic …

The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor
suppressor. Amplification of mdm2 or increased expression by unknown mechanisms …

Most human tumours have genetic mutations in their Rb and p53 pathways, but
retinoblastoma is thought to be an exception. Studies suggest that retinoblastomas, which …

Tumor suppressor p53 plays a central role in preventing tumor formation. The levels and
activity of p53 is under tight regulation to ensure its proper function. Murine double minute 2 …

The p53 pathway is disrupted in virtually every human tumor. In∼ 50% of human cancers,
the p53 gene is mutated, and in the remaining cancers, the pathway is dysregulated by …

MDM2 has been characterized as a protein that binds to and facilitates degradation of the
tumor suppressor p53. Interestingly, more than 40 different splice variants of MDM2 …

Meningiomas represent one of the most common types of primary intracranial tumours.
However, the specific molecular mechanisms underlying their pathogenesis remain …

MDM2 (HDM2) is a ubiquitin ligase that can target the p53 tumor suppressor protein for
degradation. The RING domain is essential for the E3 activity of MDM2, and we show here …

Expression of the immediate-early response gene IER2 has been associated with the
progression of several types of cancer, but its functional role is poorly understood. We found …

Lung cancer is the leading cause of cancer mortality in the world. Although exposure to
carcinogens is considered to be the main cause, genetic variation may contribute to lung …