Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …

Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …

Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation
and effective translation. Despite some progress, delivery systems are still unable to fully …

This review describes the formation of a protein corona (or its absence) on different classes
of nanoparticles, its basic principles, and its consequences for nanomedicine. For this …

The success of personalized medicine in oncology relies on using highly effective and
precise therapeutic modalities such as small interfering RNA (siRNA) and monoclonal …

Although lipid nanoparticles (LNPs) have been FDA-approved for mRNA delivery, there is
still much to learn about these fascinating multi-component delivery systems. Here, I discuss …

Understanding the interface between nanomaterials and lipoproteins is crucial for gaining
insights into their impact on lipoprotein structure and lipid metabolism. Here, we use …

Abstract Purpose of Review Emerging evidence supports the promise of precision nutritional
approaches for cardiovascular disease (CVD) prevention. Here, we discuss current findings …

Extracellular vesicles and lipoproteins are lipid-based biological nanoparticles that play
important roles in (patho) physiology. Recent evidence suggests that extracellular vesicles …

Understanding how cells process nanoparticles is crucial to optimize nanomedicine efficacy.
However, characterizing cellular pathways is challenging, especially if non-canonical …