Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Natural killer (NK) cells express an array of germ‐line encoded receptors that are capable of
triggering cytotoxicity. NK cells tend to express many members of a given family of signalling …

Blockade of PD-L1 expression on tumor cells via anti–PD-L1 monoclonal antibody (mAb)
has shown great promise for successful cancer treatment by overcoming T-cell exhaustion; …

CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that
ultimately determine functional outcomes. Here, we examined the role of the co-activating …

Tumors escape immune surveillance by inducing various immunosuppressive pathways,
including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal …

Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize
self and nonself depending on the balance of activating receptors and inhibitory receptors …

Abstract CD155 (PVR/necl5/Tage4), a member of the nectin-like family of adhesion
molecules, is highly upregulated on tumor cells across multiple cancer types and has been …

The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and
promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 …

Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell
killing and tumor destruction, are pivotal in immunity. They exhibit multifaceted roles in …

Cancer immunotherapy aims to initiate or amplify immune responses that eliminate cancer
cells and create immune memory to prevent relapse. Immune checkpoint inhibitors (ICIs) …