Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …

Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …

During prophase of the first meiotic division, cells deliberately break their DNA. These DNA
breaks are repaired by homologous recombination, which facilitates proper chromosome …

Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice
between NHEJ and HR DNA repair pathways is made. Although CDKs are known to control …

Homologous recombination (HR)-mediated DNA double-strand break repair maintains
genome integrity. Although long-studied, an understanding of two essential steps in this …

ABSTRACT DNA double-strand break (DSB) repair via the homologous recombination
pathway is a multi-stage process, which results in repair of the DSB without loss of genetic …