Micronucleus assay: the state of art, and future directions

S Sommer, I Buraczewska, M Kruszewski - International journal of …, 2020 - mdpi.com
During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans

M Fenech, S Knasmueller, C Bolognesi… - … Research/Reviews in …, 2020 - Elsevier
Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and
chromosomal instability in humans. They originate from chromosome fragments or intact …

Radiation-induced chromosomal aberrations and immunotherapy: micronuclei, cytosolic DNA, and interferon-production pathway

M Durante, SC Formenti - Frontiers in oncology, 2018 - frontiersin.org
Radiation-induced chromosomal aberrations represent an early marker of late effects,
including cell killing and transformation. The measurement of cytogenetic damage in tissues …

Potential application of γ-H2AX as a biodosimetry tool for radiation triage

V Raavi, V Perumal, SFD Paul - Mutation Research/Reviews in Mutation …, 2021 - Elsevier
Radiation triage and biological dosimetry are two initial steps in the medical management of
exposed individuals following radiological accidents. Well established biodosimetry …

Estimation of the effects of medical diagnostic radiation exposure based on DNA damage

L Shi, S Tashiro - Journal of radiation research, 2018 - academic.oup.com
X-rays are widely applied in the medical field for the diagnosis and treatment of diseases.
Among the uses of X-rays in diagnosis, computed tomography (CT) has been established as …

[HTML][HTML] The potential for complete automated scoring of the cytokinesis block micronucleus cytome assay using imaging flow cytometry

MA Rodrigues, LA Beaton-Green, RC Wilkins… - … /Genetic Toxicology and …, 2018 - Elsevier
Abstract The lymphocyte Cytokinesis-Block Micronucleus (CBMN) assay was originally
developed for the measurement of micronuclei (MN) exclusively in binucleated (BN) cells …

RENEB inter-laboratory comparison 2021: the gene expression assay

M Abend, SA Amundson, C Badie… - Radiation …, 2023 - meridian.allenpress.com
Early and high-throughput individual dose estimates are essential following large-scale
radiation exposure events. In the context of the Running the European Network for …

RENEB inter-laboratory comparison 2021: the cytokinesis-block micronucleus assay

A Vral, D Endesfelder, K Balázs… - Radiation …, 2023 - meridian.allenpress.com
The goal of the RENEB inter-laboratory comparison 2021 exercise was to simulate a large-
scale radiation accident involving a network of biodosimetry labs. Labs were required to …

Two-miRNA–based finger-stick assay for estimation of absorbed ionizing radiation dose

M Yadav, S Bhayana, J Liu, L Lu, J Huang… - Science translational …, 2020 - science.org
Nuclear radiation and radioactive fallouts resulting from a nuclear weapon detonation or
reactor accidents could result in injuries affecting multiple sensitive organs, defined as acute …

RENEB–Running the European Network of biological dosimetry and physical retrospective dosimetry

U Kulka, M Abend, E Ainsbury, C Badie… - … Journal of Radiation …, 2017 - Taylor & Francis
Purpose: A European network was initiated in 2012 by 23 partners from 16 European
countries with the aim to significantly increase individualized dose reconstruction in case of …