Intraductal papillary neoplasm of the bile duct (IPNB), a pre-invasive neoplasm of the bile
duct, is being established pathologically as a precursor lesion of invasive …

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …

Cancer incidence and mortality rates can vary widely among different racial and ethnic
groups, attributed to a complex interplay of genetic, environmental and social factors …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Epidemiological studies have identified many environmental agents that appear to
significantly increase cancer risk in human populations. By analyzing tumor genomes from …

Somatic mutations in cancer genomes are caused by multiple mutational processes each of
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …

This paper presents the first version of clinical practice guidelines for intrahepatic
cholangiocarcinoma (ICC) established by the Liver Cancer Study Group of Japan. These …

Genomic analyses have revealed mutational footprints associated with DNA maintenance
gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA …

Recent progress in cancer genome analysis using next-generation sequencing has
revealed a high mutation burden in some tumors. The particularly high rate of somatic …

Reporter gene assays, in which a single mutation from each experiment can contribute to
the assembly of a mutation spectrum for an agent, have provided the basis for …