At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Mycobacterial cutaneous lesions are nonpathognomonic and clinical suspicion must be
confirmed by culture or molecular detection. Long-course multidrug treatment is required …

Neglected tropical disease (NTD) is a set of 20 deadliest endemic diseases which shows its
presence in most of the developing countries worldwide. Nearly 1 billion of the population …

Buruli ulcer (BU), the second most common mycobacterial disease in West Africa, is a
necrotizing skin disease that can lead to high morbidity in affected patients. The disease is …

Mycobacterial disease is an immense burden worldwide. This disease group includes
tuberculosis, leprosy (Hansen's disease), Buruli Ulcer, and non-tuberculous mycobacterial …

Autophagy is critically involved in host defense pathways through targeting and elimination
of numerous pathogens via autophagic machinery. Nontuberculous mycobacteria (NTMs) …

Buruli ulcer (BU), a neglected tropical disease (NTD), is an infection of the skin and
subcutaneous tissue caused by Mycobacterium ulcerans. The disease has been …

The Mycobacterium ulcerans exotoxin, mycolactone, is responsible for the
immunosuppression and tissue necrosis that characterizes Buruli ulcer. Mycolactone inhibits …

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin
disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both …

Buruli ulcer, the third most common mycobacterial disease worldwide, is caused by
Mycobacterium ulcerans and characterized by devastating necrotizing skin lesions …