Enhancing the regeneration of axons is often considered to be a therapeutic target for
improving functional recovery after peripheral nerve injury. In this review, the evidence for …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Background Increasing pre-clinical evidence suggests that aerobic exercise positively
modulates neuroimmune responses following traumatic nerve injury. However, meta …

Pre-clinical evidence shows that neuropathy is associated with complex neuroimmune
responses, which in turn are associated with increased intensity and persistence of …

Appropriate animal models, mimicking conditions of both health and disease, are needed to
understand not only the biology and the physiology of neurons and other cells under normal …

Injured peripheral nerves regenerate their axons in contrast to those in the central nervous
system. Yet, functional recovery after surgical repair is often disappointing. The basis for …

One hour of 20-Hz continuous electrical stimulation (ES) applied at the time of injury
promotes the regeneration of axons in cut peripheral nerves. A more robust enhancement of …

Peripheral nerve injuries are common, and functional recovery is very poor. Beyond surgical
repair of the nerve, there are currently no treatment options for these patients. In …

Recovery of mimic function after facial nerve transection is poor. The successful regrowth of
regenerating motor nerve fibers to reinnervate their targets is compromised by (i) poor …

Brief neuronal activation in injured peripheral nerves is both necessary and sufficient to
enhance motor axon regeneration, and this effect is specific to the activated motoneurons. It …