Unlocking glioblastoma vulnerabilities with CRISPR-based genetic screening

Y Fang, X Li, R Tian - International Journal of Molecular Sciences, 2024 - mdpi.com
Glioblastoma (GBM) is the most common malignant brain tumor in adults. Despite
advancements in treatment, the prognosis for patients with GBM remains poor due to its …

Should I stay or should I go? Transsulfuration influences invasion and growth in glioblastoma

AK Ponti, DJ Silver, C Hine… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
A major challenge in treating patients with glioblastoma is the inability to eliminate highly
invasive cells with chemotherapy, radiation, or surgical resection. As cancer cells face the …

Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

AH Janneh - BioChem, 2024 - mdpi.com
Glioblastoma is the most common and aggressive type of malignant brain tumor with a poor
prognosis due to the lack of effective treatment options. Therefore, new treatment options are …

[HTML][HTML] Lipidomics-driven drug discovery and delivery strategies in glioblastoma

X Weng, M Gonzalez, J Angelia, S Piroozmand… - … et Biophysica Acta (BBA …, 2024 - Elsevier
With few viable treatment options, glioblastoma (GBM) is still one of the most aggressive and
deadly types of brain cancer. Recent developments in lipidomics have demonstrated the …

[HTML][HTML] Nitroxoline evidence Amoebicidal Activity against Acanthamoeba castellanii through DNA damage and the stress response pathways

L Chen, W Han, W Jing, M Feng, Q Zhou… - International Journal for …, 2025 - Elsevier
Acanthamoeba castellanii is a widespread unicellular eukaryote found in diverse
environments, including tap water, soil, and swimming pools. It is responsible for severe …

[HTML][HTML] Dissecting TGF-β-induced glioblastoma invasion with engineered hyaluronic acid hydrogels

KY Amofa, KM Patterson, J Ortiz, S Kumar - APL bioengineering, 2024 - pubs.aip.org
Glioma stem cells (GSCs) contribute to rapid cellular invasion in glioblastoma (GBM).
Transforming growth factor-β (TGF-β) has been strongly implicated in supporting key GSC …

A reactive oxygen species-related signature predicts the prognosis and immunosuppressive microenvironment in gliomas

X Shan, R Huang, K Wang, P Yang - Redox Report, 2024 - Taylor & Francis
Objective: Intracellular redox homeostasis is crucial for a series of physiological processes.
Reactive oxygen species (ROS) play important roles in redox processes. ROS can maintain …

Diet-Modifiable Redox Alterations in Ageing and Cancer

C Hine, AK Patel, AK Ponti - Biochemistry and Cell Biology of Ageing: Part …, 2024 - Springer
With ageing comes some of life's best and worst moments. Those lucky enough to live out
into the seventh, eighth, and nineth decades and perhaps beyond have more opportunities …

[HTML][HTML] An engineered glioblastoma model yields novel macrophage-secreted drivers of invasion

EA Akins, D Wilkins, MK Aghi, S Kumar - bioRxiv, 2023 - ncbi.nlm.nih.gov
Glioblastomas (GBMs) are highly invasive brain tumors replete with brain-and blood-derived
macrophages, collectively known as tumor-associated macrophages (TAMs). Targeting …

MAT2a and AHCY inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival

EC Rowland, M D'Antuono, A Jermakowicz, NG Ayad - bioRxiv, 2024 - biorxiv.org
Glioblastoma (GBM) is a highly aggressive primary malignant adult brain tumor that
inevitably recurs with a fatal prognosis. This is due in part to metabolic reprogramming that …