Prodrug strategies for targeted therapy triggered by reactive oxygen species
JP Cadahía, V Previtali, NS Troelsen, MH Clausen - MedChemComm, 2019 - pubs.rsc.org
Increased levels of reactive oxygen species (ROS) have been associated with numerous
pathophysiological conditions including cancer and inflammation and the ROS stimulus …
pathophysiological conditions including cancer and inflammation and the ROS stimulus …
Synthesis and Structure of Arene Ru(II) N∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism
A panel of six new structurally related organometallic arene Ru (II) complexes of general
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …
Novel tetranuclear ruthenium (II) arene complexes showing potent cytotoxic and antimetastatic activity as well as low toxicity in vivo
MKM Subarkhan, L Ren, B Xie, C Chen, Y Wang… - European journal of …, 2019 - Elsevier
Ruthenium complexes have attracted a surge of interest as anticancer drug candidates
because of their low toxicity, diversity in mode-of-actions and non-cross drug resistance with …
because of their low toxicity, diversity in mode-of-actions and non-cross drug resistance with …
Diverse coordination of isoniazid hydrazone Schiff base ligand towards iron (III): Synthesis, characterization, SC-XRD, HSA, QTAIM, MEP, NCI, NBO and DFT study
H Kargar, M Fallah-Mehrjardi… - Journal of Molecular …, 2022 - Elsevier
A new iron (III) complex has been successfully prepared by the reaction of an ONO donor
Schiff base, derived by condensing isoniazid and 3-ethoxysalicylaldehyde, with Fe (acac) 3 …
Schiff base, derived by condensing isoniazid and 3-ethoxysalicylaldehyde, with Fe (acac) 3 …
Synthesis and structure of new binuclear ruthenium (II) arene benzil bis (benzoylhydrazone) complexes: investigation on antiproliferative activity and apoptosis …
MSM Kasim, S Sundar, R Rengan - Inorganic chemistry frontiers, 2018 - pubs.rsc.org
A series of binuclear ruthenium (II) arene benzil bis (benzoylhydrazone) complexes (1–6) of
the common composition [(η6-arene) 2Ru2 (L) Cl2](arene= benzene or p-cymene; L= benzil …
the common composition [(η6-arene) 2Ru2 (L) Cl2](arene= benzene or p-cymene; L= benzil …
Stimulus-responsive prochelators for manipulating cellular metals
Q Wang, KJ Franz - Accounts of chemical research, 2016 - ACS Publications
Conspectus Metal ions are essential for a wide range of physiological processes, but they
can also be toxic if not appropriately regulated by a complex network of metal trafficking …
can also be toxic if not appropriately regulated by a complex network of metal trafficking …
DNA and BSA binding and cytotoxic properties of copper (II) and iron (III) complexes with arylhydrazone of ethyl 2-cyanoacetate or formazan ligands
NMR Martins, S Anbu, KT Mahmudov… - New Journal of …, 2017 - pubs.rsc.org
Several known water soluble [Cu (1κN, O2: 2κO-HL1)(S)] 2 [S= CH3OH (1),(CH3) 2NCHO
(2)] and [Cu (κN-HL1)(en) 2]· CH3OH· H2O (3) CuII complexes were prepared by reaction of …
(2)] and [Cu (κN-HL1)(en) 2]· CH3OH· H2O (3) CuII complexes were prepared by reaction of …
Synthesis and comparison of antioxidant properties of Indole‐based melatonin analogue Indole amino acid derivatives
S Suzen, SS Cihaner, T Coban - Chemical biology & drug …, 2012 - Wiley Online Library
Increased levels of reactive oxygen species attributed to oxidative stress have been found to
be responsible for the development of some vital diseases such as cardiovascular …
be responsible for the development of some vital diseases such as cardiovascular …
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications
K Hrušková, E Potůčková, T Hergeselova… - European journal of …, 2016 - Elsevier
Aroylhydrazones such as salicylaldehyde isonicotinoyl hydrazone (SIH) are tridentate iron
chelators that may possess antioxidant and/or antineoplastic activities. Their main drawback …
chelators that may possess antioxidant and/or antineoplastic activities. Their main drawback …
Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action
E Macková, K Hrušková, P Bendová, A Vávrová… - Chemico-biological …, 2012 - Elsevier
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, orally-active tridentate iron
chelator providing both effective protection against various types of oxidative stress-induced …
chelator providing both effective protection against various types of oxidative stress-induced …