Tumor cells manipulate the local environment in which they grow, creating a tumor
microenvironment (TME) that promotes tumor survival and metastasis. The TME is an …

Cancer immunotherapy and the emergence of immune checkpoint inhibitors have markedly
changed the treatment paradigm for many cancers. They function to disrupt cancer cell …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Oncolytic virus (OV) therapy is an emerging anti-cancer approach that utilizes viruses to
preferentially infect and kill cancer cells, while not harming healthy cells. Vesicular stomatitis …

Highlights•NK cells can kill virus-infected cells and protect against severe infections.•Long-
lived memory NK cells may develop after vaccination or infection.•NK cells are potent …

The three-way interaction between oncolytic viruses, the tumor microenvironment, and the
immune system is critical to the outcome of antitumor therapy. Classically, the immune …

Oncolytic viruses (OVs) are highly immunogenic and this limits their use in immune-
competent hosts. Although immunosuppression may improve viral oncolysis, this gain is …

To expand our current array of safe and potent oncolytic viruses, we screened a variety of
wild-type (WT) rhabdoviruses against a panel of tumor cell lines. Our screen identified a …

Targeted therapy of cancer using oncolytic viruses has generated much interest over the
past few years in the light of the limited efficacy and side effects of standard cancer …

The role of the immune response to oncolytic Herpes simplex viral (oHSV) therapy for
glioblastoma is controversial because it might enhance or inhibit efficacy. We found that …