Linking actin dynamics and gene transcription to drive cellular motile functions
EN Olson, A Nordheim - Nature reviews Molecular cell biology, 2010 - nature.com
Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …
Mechanosensitive mechanisms in transcriptional regulation
Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …
The biology of pediatric acute megakaryoblastic leukemia
TA Gruber, JR Downing - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
Mechanical control of epithelial-to-mesenchymal transitions in development and cancer
L Przybyla, JM Muncie… - Annual review of cell and …, 2016 - annualreviews.org
Mechanical force modulates development, influences tissue homeostasis, and contributes to
disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging …
disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging …
[HTML][HTML] The molecular signature of oncofusion proteins in acute myeloid leukemia
JHA Martens, HG Stunnenberg - FEBS letters, 2010 - Elsevier
Acute myeloid leukemia (AML) associated translocations often cause gene fusions that
encode oncofusion proteins. Although many of the breakpoints involved in chromosomal …
encode oncofusion proteins. Although many of the breakpoints involved in chromosomal …
Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction
A Descot, R Hoffmann, D Shaposhnikov, M Reschke… - Molecular cell, 2009 - cell.com
We analyzed the G-actin-regulated transcriptome by gene expression analysis using
previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent …
previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent …
MRTF: basic biology and role in kidney disease
A lesser known but crucially important downstream effect of Rho family GTPases is the
regulation of gene expression. This major role is mediated via the cytoskeleton, the …
regulation of gene expression. This major role is mediated via the cytoskeleton, the …
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model
T Mercher, GD Raffel, SA Moore… - The Journal of …, 2009 - Am Soc Clin Investig
Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML)
associated with a poor prognosis. The genetics and pathophysiology of AMKL are not well …
associated with a poor prognosis. The genetics and pathophysiology of AMKL are not well …
SPOC domain proteins in health and disease
LM Appel, J Benedum, M Engl, S Platzer… - Genes & …, 2023 - genesdev.cshlp.org
Since it was first described> 20 yr ago, the SPOC domain (Spen paralog and ortholog C-
terminal domain) has been identified in many proteins all across eukaryotic species. SPOC …
terminal domain) has been identified in many proteins all across eukaryotic species. SPOC …
Activation and repression of cellular immediate early genes by serum response factor cofactors
SM Lee, M Vasishtha, R Prywes - Journal of Biological Chemistry, 2010 - ASBMB
The induction of expression of many cellular immediate early genes (IEG) involves the
transcription factor serum response factor (SRF). Two families of SRF coactivators have also …
transcription factor serum response factor (SRF). Two families of SRF coactivators have also …