A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …

Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

The ubiquitin-proteasome system has numerous crucial roles in physiology and
pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases …

Regulated protein degradation has emerged as a key recurring theme in multiple aspects of
cell-cycle regulation. Importantly, the irreversible nature of proteolysis makes it an invaluable …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

The anaphase promoting complex/cyclosome (APC/C), is an evolutionarily conserved
protein complex essential for cellular division due to its role in regulating the mitotic …

Background Liver hepatocellular carcinoma (HCC) is a prevalent cancer that lacks a
sufficiently efficient approach to guide immunotherapy. Additionally, cuproptosis is a recently …

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein
ligase that targets different substrates for ubiquitylation and therefore regulates a variety of …

Background: Dicer, a ribonuclease, is the key enzyme required for the biogenesis of
microRNAs and small interfering RNAs and is essential for both mammalian development …

Cell proliferation is known to be accompanied by activation of glycolysis. We have recently
discovered that the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2, 6 …