Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as
major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding …

Next-generation sequencing (NGS) can identify novel cancer targets. However, interpreting
the molecular findings and accessing drugs/clinical trials is challenging. Furthermore, many …

Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …

Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

Molecular targeted therapy heralded a new era for the treatment of patients with oncogene-
driven advanced-stage non–small-cell lung cancer (NSCLC). Molecular testing at the time of …

(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …

The ROS-1 gene plays a major role in the oncogenesis of numerous tumors. ROS-1
rearrangement is found in 0.9–2.6% of non-small-cell lung cancers (NSCLCs), mostly lung …

The neurotrophic tyrosine receptor kinase (NTRK) gene family encodes three tropomyosin
receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous …

Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few
years have seen the development of a new staging system, diagnostic procedures such as …