Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients

T Lawn, A Giacomel, D Martins, M Veronese… - Communications …, 2024 - nature.com
Advanced methods such as REACT have allowed the integration of fMRI with the brain's
receptor landscape, providing novel insights transcending the multiscale organisation of the …

Emerging Perspectives on Neuroprotection

G Hasler, D Inta - Psychotherapy and Psychosomatics, 2024 - karger.com
Neuroprotection aims to safeguard neurons from damage caused by various factors like
stress, potentially leading to the rescue, recovery, or regeneration of the nervous system and …

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

JY Magdaleno Roman, C Chapa González - Neuroprotection, 2024 - Wiley Online Library
Recent advances in neuroscience have illuminated the central role of glutamate
dysregulation in various neurological disorders. The glutamatergic system has emerged as …

Molecular mechanisms of quetiapine bidirectional regulation of bipolar depression and mania based on network pharmacology and molecular docking: Evidence from …

C Li, H Tian, R Li, F Jia, L Wang, X Ma, L Yang… - Journal of Affective …, 2024 - Elsevier
Background Quetiapine monotherapy is recommended as the first-line option for acute
mania and acute bipolar depression. However, the mechanism of action of quetiapine is …

Bidirectional two-sample Mendelian randomization analysis identifies causal associations between migraine and five psychiatric disorders

WW Li, JX Zhang, J Wang, Y Chen, S Lai… - Frontiers in …, 2024 - frontiersin.org
Background The question of whether a correlation exists between migraine and five
psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive …

Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1

JM Wang, YM Wang, YB Zhu, C Cui… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims This study aimed to investigate the relationship between ulcerative colitis (UC) and
anxiety and explore its central mechanisms using colitis mice. Methods Anxiety‐like …

Mood instability as prodrome of bipolar disorder

R Guglielmo, A Escelsior, M Amore… - Journal of …, 2024 - jpsychopathol.it
Bipolar disorder and affective disorders exhibit progressive trajectories, involving central
and peripheral biological changes and diverse clinical courses. This review explores the …

The glutamate hypothesis of mood disorders: Neuroplasticity processes, clinical features, treatment perspectives

R Guglielmo, R de Filippis, S Ouanes… - Frontiers in Psychiatry, 2022 - frontiersin.org
The monoamine hypothesis has dominated the research on the pathophysiology of mood
disorders as well as the development of therapeutic drugs by over half a century. The …

Normative Modelling of Molecular-based Functional Neurocircuits Captures Clinical Heterogeneity Transdiagnostically in Neuropsychiatric Patients

T Lawn, A Giacomel, D Martins, M Veronese… - bioRxiv, 2023 - biorxiv.org
Clinical neuroscience principally aims to delineate the neurobiology underpinning the
symptoms of various disorders, with the ultimate goal of developing mechanistically …

Program de neuroprotecţie şi neuroreabilitare bazat pe acţiunea multimodală combinată a factorilor de mediu, activitate zilnică individuală şi alimentaţie ecologică …

A Baciu - 2024 - repository.usmf.md
Structura tezei: introducere, trei capitole, concluzii generale şi recomandări practice,
bibliografie din 497 de titluri, 5 anexe, 234 pagini de text de bază, 89 figuri, 9 tabele …