Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Within living cells, mitochondria are considered relevant sources of reactive oxygen species
(ROS) and are exposed to reactive nitrogen species (RNS). During the last decade …

For the vast majority of patients with mitochondrial diseases, only supportive and
symptomatic therapies are available. However, in the last decade, due to extraordinary …

Complex I deficiency is the most frequently encountered single mitochondrial single enzyme
deficiency in patients with a mitochondrial disorder. Although specific genotype–phenotype …

Currently, it is known that, in living systems, free radicals and other reactive oxygen and
nitrogen species play a double role, because they can cause oxidative damage and tissue …

Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …

Mitochondrial disorders are an important group of genetic conditions characterized by
impaired oxidative phosphorylation. Mitochondrial disorders come with an impressive …

This review presents our current understanding of the pathophysiology and potential
treatment strategies with respect to mitochondrial disease in children. We focus on …

The morphology of a population of mitochondria is the result of several interacting dynamical
phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these …

Mitochondria have a central role in cellular (patho) physiology, and they display a highly
variable morphology that is probably coupled to their functional state. Here we present a …