Translating biosynthetic gene clusters into fungal armor and weaponry

NP Keller - Nature chemical biology, 2015 - nature.com
Filamentous fungi are renowned for the production of a diverse array of secondary
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …

On the trail of a cereal killer: recent advances in Fusarium graminearum pathogenomics and host resistance

K Kazan, DM Gardiner… - Molecular plant …, 2012 - Wiley Online Library
The ascomycete fungal pathogen Fusarium graminearum (sexual stage: Gibberella zeae)
causes the devastating head blight or scab disease on wheat and barley, and cob or ear rot …

Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products

F Guzmán-Chávez, RD Zwahlen… - Frontiers in …, 2018 - frontiersin.org
Penicillium chrysogenum (renamed P. rubens) is the most studied member of a family of
more than 350 Penicillium species that constitute the genus. Since the discovery of penicillin …

A Nonribosomal Peptide Synthetase-Derived Iron(III) Complex from the Pathogenic Fungus Aspergillus fumigatus

WB Yin, JA Baccile, JW Bok, Y Chen… - Journal of the …, 2013 - ACS Publications
Small molecules (SMs) play central roles as virulence factors of pathogenic fungi and
bacteria; however, genomic analyses suggest that the majority of microbial SMs have …

Identification of ABC Transporter Genes of Fusarium graminearum with Roles in Azole Tolerance and/or Virulence

G Abou Ammar, R Tryono, K Döll, P Karlovsky… - PloS one, 2013 - journals.plos.org
Fusarium graminearum is a plant pathogen infecting several important cereals, resulting in
substantial yield losses and mycotoxin contamination of the grain. Triazole fungicides are …

Bacillus subtilis HSY21 can reduce soybean root rot and inhibit the expression of genes related to the pathogenicity of Fusarium oxysporum

S Han, J Chen, Y Zhao, H Cai, C Guo - Pesticide biochemistry and …, 2021 - Elsevier
Soybean root rot occurs globally and seriously affects soybean production. To avoid the
many disadvantages of chemical fungicides, the addition of Bacillus is gradually becoming …

Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum

J Tannous, R El Khoury, SP Snini, Y Lippi… - International Journal of …, 2014 - Elsevier
Patulin is a polyketide-derived mycotoxin produced by numerous filamentous fungi. Among
them, Penicillium expansum is by far the most problematic species. This fungus is a …

Fusarium graminearum Tri12p Influences Virulence to Wheat and Trichothecene Accumulation

J Menke, Y Dong, HC Kistler - Molecular plant-microbe …, 2012 - Am Phytopath Society
The gene Tri12 encodes a predicted major facilitator superfamily protein suggested to play a
role in export of trichothecene mycotoxins produced by Fusarium spp. It is unclear, however …

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

RA Cacho, Y Tang, YH Chooi - Frontiers in microbiology, 2015 - frontiersin.org
Genomics has revolutionized the research on fungal secondary metabolite (SM)
biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the …

The ORF2 protein of Fusarium graminearum virus 1 suppresses the transcription of FgDICER2 and FgAGO1 to limit host antiviral defences

J Yu, JY Park, JI Heo, KH Kim - Molecular plant pathology, 2020 - Wiley Online Library
The filamentous fungus Fusarium graminearum possesses an RNA‐interference (RNAi)
pathway that acts as a defence response against virus infections and exogenous double …