Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 6,107,094, 2000 - Google Patents
Mackiewicz & Norris LLP 57 ABSTRACT Oligomeric compounds including
oligoribonucleotides and oligoribonucleosides are provided that have Subsequences of 2' …
oligoribonucleotides and oligoribonucleosides are provided that have Subsequences of 2' …
Oligoribonucleotides for cleaving RNA
ST Crooke - US Patent 5,898,031, 1999 - Google Patents
This invention is directed to the synthesis and use of oligomeric compounds, including
oligoribonucleotides and oligoribonucleosides, useful for Strand cleavage of target RNA …
oligoribonucleotides and oligoribonucleosides, useful for Strand cleavage of target RNA …
2'-O-acetamido modified monomers and oligomers
M Manoharan, AM Kawasaki, PD Cook… - US Patent …, 2000 - Google Patents
Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also
provided is a novel method of deprotection of oligomeric compounds. Oligomeric com …
provided is a novel method of deprotection of oligomeric compounds. Oligomeric com …
Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2013 - Google Patents
2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Positionally modified siRNA constructs
B Bhat, EE Swayze, TP Prakash, C Allerson… - US Patent …, 2013 - Google Patents
The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
Aminooxy-modified oligonucleotides and methods for making same
M Manoharan, PD Cook, TP Prakash… - US Patent …, 2001 - Google Patents
Oligonucleotides and other macromolecules are provided which have increased nuclease
resistance, substituent groups (such as 2'-aminooxy groups) for increasing binding affinity to …
resistance, substituent groups (such as 2'-aminooxy groups) for increasing binding affinity to …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,432,250, 2008 - Google Patents
(*) Notice: Subject to any disclaimer, the term of this 5,457,191. A 10/1995 Cook et al. patent
is extended or adjusted under 35 5,459.255. A 10/1995 Cook et al. USC 154 (b) by 594 …
is extended or adjusted under 35 5,459.255. A 10/1995 Cook et al. USC 154 (b) by 594 …
Modified RNAi polynucleotides and uses thereof
The invention relates to improved RNAi constructs and uses thereof. The construct has a
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …