Dopamine in health and disease: much more than a neurotransmitter

R Franco, I Reyes-Resina, G Navarro - Biomedicines, 2021 - mdpi.com
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through
the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher …

Reward deficiency syndrome: genetic aspects of behavioral disorders

DE Comings, K Blum - Progress in brain research, 2000 - Elsevier
The dopaminergic and opiodergic reward pathways of the brain are critical for survival since
they provide the pleasure drives for eating, love and reproduction; these are called 'natural …

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking

RP Ebstein, O Novick, R Umansky, B Priel, Y Osher… - Nature …, 1996 - nature.com
Human personality traits which can be reliably measured by any of a number of rating
scales, show a considerable heritable component1, 2. The tridimensional personality …

Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking

J Benjamin, L Li, C Patterson, BD Greenberg… - Nature …, 1996 - nature.com
Twin and adoption studies suggest that 30 to 60% of the variance in many personality traits
is due to inherited factors. However, there is little knowledge of the number or identity of the …

Attention deficit hyperactivity disorder: advances in cognitive, neurobiological, and genetic research

R Tannock - The Journal of Child Psychology and Psychiatry and …, 1998 - cambridge.org
Conceptual and technological advances in cognitive neuroscience and molecular genetics
have the potential to identify the pathogenesis of psychiatric disorders. This article reviews …

Dopamine receptor pharmacology

P Seeman, HHM Van Tol - Trends in pharmacological sciences, 1994 - cell.com
Brain dopamine receptors are the primary targets in the medical treatment of schizophret~
Parkinson's di~, a~ e H=~ aSto~'s chorea.~ ptor ant~,, or~(or neuroleptics) such as halope …

Evidence of positive selection acting at the human dopamine receptor D4 gene locus

YC Ding, HC Chi, DL Grady… - Proceedings of the …, 2002 - National Acad Sciences
Associations have been reported of the seven-repeat (7R) allele of the human dopamine
receptor D4 (DRD4) gene with both attention-deficit/hyperactivity disorder and the …

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

FM Chang, JR Kidd, KJ Livak, AJ Pakstis, KK Kidd - Human genetics, 1996 - Springer
The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon
that may have functional relevance. The polymorphism exists at two levels. At the higher …

The dopamine D4 receptor: one decade of research

JN Oak, J Oldenhof, HHM Van Tol - European journal of pharmacology, 2000 - Elsevier
Dopamine is an important neurotransmitter involved in motor control, endocrine function,
reward, cognition and emotion. Dopamine receptors belong to the superfamily of G protein …

Genetics of dopamine receptors and drug addiction: a comprehensive review

B Le Foll, A Gallo, Y Le Strat, L Lu… - Behavioural …, 2009 - journals.lww.com
Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …