During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Cancer is a genetic disease stemming from cumulative genetic/epigenetic aberrations.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated …

The majority of the human genome does not encode proteins. Many of these noncoding
regions contain important regulatory sequences that control gene expression. To date, most …

Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug
resistance arising in the tumor. Understanding the molecular basis of drug resistance and …

Drug resistance is a major challenge in breast cancer (BC) treatment at present.
Accumulating studies indicate that breast cancer stem cells (BCSCs) are responsible for the …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths
worldwide. Although recent advances in therapeutic approaches for treating HCC have …

Abstract Background Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
is derived from the bacterial innate immune system and engineered as a robust gene-editing …

Epigenetic modulators perform critical functions in gene expression for rapid adaption to
external stimuli and are prevalent in all higher-order organisms. The establishment of a link …

Cancer is characterized by multiple genetic and epigenetic alterations that drive malignant
cell proliferation and confer chemoresistance. The ability to correct or ablate such mutations …

Background and purpose Asiatic acid is one of the active compounds isolated from Centella
asiatica and has been used to treat many diseases, including hypertension, pulmonary …