Acute graft-versus-host disease

F Malard, E Holler, BM Sandmaier, H Huang… - Nature Reviews …, 2023 - nature.com
Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3–Internal Tandem Duplication Mutation …

A Burchert, G Bug, LV Fritz, J Finke… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT),
patients with acute myeloid leukemia (AML) with internal tandem duplication mutation in the …

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

A Galleu, Y Riffo-Vasquez, C Trento, C Lomas… - Science translational …, 2017 - science.org
The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented.
However, the therapeutic benefit is completely unpredictable, thus raising concerns about …

[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and …

MH Jagasia, HT Greinix, M Arora, KM Williams… - Biology of Blood and …, 2015 - Elsevier
Abstract The 2005 National Institutes of Health (NIH) Consensus Conference proposed new
criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD) …

EBMT− NIH− CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment

HM Schoemans, SJ Lee, JL Ferrara, D Wolff… - Bone marrow …, 2018 - nature.com
Several international recommendations address the assessment of graft-versus-host
disease (GvHD) after hematopoietic cell transplantation (HCT). This position statement by …

Ipilimumab for patients with relapse after allogeneic transplantation

MS Davids, HT Kim, P Bachireddy… - … England Journal of …, 2016 - Mass Medical Soc
Background Loss of donor-mediated immune antitumor activity after allogeneic
hematopoietic stem-cell transplantation (HSCT) permits relapse of hematologic cancers. We …

Allogeneic T cells that express an anti-CD19 chimeric antigen receptor induce remissions of B-cell malignancies that progress after allogeneic hematopoietic stem-cell …

JN Brudno, RPT Somerville, V Shi, JJ Rose… - Journal of clinical …, 2016 - ascopubs.org
Purpose Progressive malignancy is the leading cause of death after allogeneic
hematopoietic stem-cell transplantation (alloHSCT). After alloHSCT, B-cell malignancies …

Survival, nonrelapse mortality, and relapse-related mortality after allogeneic hematopoietic cell transplantation: comparing 2003–2007 versus 2013–2017 cohorts

GB McDonald, BM Sandmaier, M Mielcarek… - Annals of internal …, 2020 - acpjournals.org
Background: Allogeneic hematopoietic cell transplantation is indicated for refractory
hematologic cancer and some nonmalignant disorders. Survival is limited by recurrent …

[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …

KR Cooke, L Luznik, S Sarantopoulos, FT Hakim… - Biology of Blood and …, 2017 - Elsevier
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …