This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …

Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Prodrug and drug delivery systems are two effective strategies for improving the selectivity of
chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising …

A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

The polysaccharide-based biomaterials hyaluronic acid (HA) and chondroitin sulfate (CS)
have aroused great interest for use in drug delivery systems for tumor therapy, as they have …

The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …

In this era, broad‐spectrum prodrugs with anti‐severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) activities are gaining considerable attention owing to their …

Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, stands as an
immensely devastating and persistently relevant pathogen, claiming the lives of millions …

Extensive research into prodrug modification of active pharmaceutical ingredients and
nanoparticle drug delivery systems has led to unprecedented levels of control over the …