Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …

Research into the biological role of the Ca2+-releasing second messenger NAADP
(nicotinic acid adenine dinucleotide phosphate) has been hampered by a lack of chemical …

The endoplasmic reticulum (ER) mediates the first steps of protein assembly within the
secretory pathway and is the site where protein folding and quality control are initiated. The …

How different extracellular stimuli can evoke different spatiotemporal Ca 2+ signals is
uncertain. We have elucidated a novel paradigm whereby different agonists use different Ca …

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …

ABSTRACT [Ca 2+] i and electrical activity were compared in isolated β-cells and islets
using standard techniques. In islets, raising glucose caused a decrease in [Ca 2+] i followed …

Aims/hypothesis Pancreatic beta cells respond to endoplasmic reticulum (ER) stress by
activating the unfolded protein response. If the stress is prolonged, or the adaptive response …

Aims/hypothesis ATP links changes in glucose metabolism to electrical activity, Ca 2+
signalling and insulin secretion in pancreatic beta cells. There is evidence that beta cell …

OBJECTIVE Sarco-endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b) and SERCA3
pump Ca2+ in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in …