Abstract Purpose of Review To discuss current knowledge and recent findings regarding the
epidemiology of hepatocellular carcinoma (HCC) in the USA. Recent Finding The US …

Fibrosis, which leads to progressive loss of tissue function and eventual organ failure, has
been estimated to contribute to~ 45% of deaths in the developed world, and so new …

Background It is well known that the incidence of developing hepatocelluler carcinoma
(HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC …

Bile acids have emerged as important signaling molecules in the host, as they interact either
locally or systemically with specific cellular receptors, in particular the farnesoid X receptor …

Background: Many recent studies suggest the immune system plays a significant role in the
pathogenesis of autoimmune diseases, chronic inflammatory diseases, and cancer …

Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary
biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to …

Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver
disease characterized by a triad of chronic cholestasis, circulating anti-mitochondrial …

The prevalence, clinical characteristics, and outcomes of patients with antimitochondrial
antibodies (AMAs), but no clinical evidence of primary biliary cholangitis (PBC), are largely …

The discovery of nuclear receptors and transporters has contributed to the development of
new drugs for the treatment of cholestatic liver diseases. Particular progress has been made …

Clinical studies have indicated that circulating bile acid (BA) concentrations increase
following bariatric surgery, especially following malabsorptive procedures such as Roux-en …