Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Fungi that infect humans

JR Köhler, B Hube, R Puccia, A Casadevall… - Microbiology …, 2017 - Am Soc Microbiol
Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …

C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

JV Desai, D Kumar, T Freiwald, D Chauss… - Cell, 2023 - cell.com
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …

Molecular mechanisms of mucormycosis—The bitter and the sweet

C Baldin, AS Ibrahim - PLoS pathogens, 2017 - journals.plos.org
During the past 2 decades, mucormycosis has become the third most common invasive
fungal infection in patients with hematological malignancies and organ transplantations [1] …

Best practices on the differential expression analysis of multi-species RNA-seq

M Chung, VM Bruno, DA Rasko, CA Cuomo, JF Muñoz… - Genome biology, 2021 - Springer
Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …

Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa

JP Richardson, HME Willems, DL Moyes… - Infection and …, 2018 - Am Soc Microbiol
Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal
pathogen Candida albicans, is a disease of immunocompetent and otherwise healthy …

Candida albicans–epithelial interactions and induction of mucosal innate immunity

JR Naglik, A König, B Hube, SL Gaffen - Current opinion in microbiology, 2017 - Elsevier
Highlights•Candidalysin is the first peptide toxin identified in any human fungal
pathogen.•Epithelial cells identify invasive C. albicans by detecting Candidalysin …

Metatranscriptomics for the human microbiome and microbial community functional profiling

Y Zhang, KN Thompson, T Branck, Y Yan… - Annual Review of …, 2021 - annualreviews.org
Shotgun metatranscriptomics (MTX) is an increasingly practical way to survey microbial
community gene function and regulation at scale. This review begins by summarizing the …

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

M Pekmezovic, H Hovhannisyan, MS Gresnigt… - Nature …, 2021 - nature.com
Vaginal candidiasis is an extremely common disease predominantly caused by four
phylogenetically diverse species: Candida albicans; Candida glabrata; Candida …

IL-17 receptor signaling in oral epithelial cells is critical for protection against oropharyngeal candidiasis

HR Conti, VM Bruno, EE Childs, S Daugherty… - Cell host & …, 2016 - cell.com
Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal
candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type (s) that …