Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars

ZS Patel, TJ Brunstetter, WJ Tarver, AM Whitmire… - npj …, 2020 - nature.com
NASA's plans for space exploration include a return to the Moon to stay—boots back on the
lunar surface with an orbital outpost. This station will be a launch point for voyages to …

Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

AG Lee, TH Mader, CR Gibson, W Tarver, P Rabiei… - npj …, 2020 - nature.com
Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual
physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity …

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

FE Garrett-Bakelman, M Darshi, SJ Green, RC Gur… - Science, 2019 - science.org
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

Human pathophysiological adaptations to the space environment

GC Demontis, MM Germani, EG Caiani… - Frontiers in …, 2017 - frontiersin.org
Space is an extreme environment for the human body, where during long-term missions
microgravity and high radiation levels represent major threats to crew health. Intriguingly …

Artificial intelligence frameworks to detect and investigate the pathophysiology of spaceflight associated neuro-ocular syndrome (SANS)

J Ong, E Waisberg, M Masalkhi, SA Kamran, K Lowry… - Brain Sciences, 2023 - mdpi.com
Spaceflight associated neuro-ocular syndrome (SANS) is a unique phenomenon that has
been observed in astronauts who have undergone long-duration spaceflight (LDSF). The …

Human health during space travel: state-of-the-art review

C Krittanawong, NK Singh, RA Scheuring, E Urquieta… - Cells, 2022 - mdpi.com
The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Spaceflight-induced intracranial hypertension and visual impairment: pathophysiology and countermeasures

LF Zhang, AR Hargens - Physiological reviews, 2018 - journals.physiology.org
Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

Benefits for bone from resistance exercise and nutrition in long‐duration spaceflight: evidence from biochemistry and densitometry

SM Smith, MA Heer, LC Shackelford… - Journal of Bone and …, 2012 - academic.oup.com
Exercise has shown little success in mitigating bone loss from long‐duration spaceflight. The
first crews of the International Space Station (ISS) used the “interim resistive exercise …

Long-term space nutrition: a scoping review

H Tang, HH Rising, M Majji, RD Brown - Nutrients, 2021 - mdpi.com
This scoping review aimed to identify current evidence and gaps in the field of long-term
space nutrition. Specifically, the review targeted critical nutritional needs during long-term …

Astronaut omics and the impact of space on the human body at scale

LA Rutter, H Cope, MJ MacKay, R Herranz… - Nature …, 2024 - nature.com
Future multi-year crewed planetary missions will motivate advances in aerospace nutrition
and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in …