The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays
a central role in a regulatory network governing the transcriptional control of mitochondrial …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

The importance of personalized medicine has been growing, mainly due to a more urgent
need to avoid unnecessary and expensive treatments. In nuclear medicine, the theranostic …

Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Around 98% of all transcriptional output in humans is non-coding RNA. RNA-mediated gene
regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA …

Context: Thyroid disease and the metabolic syndrome are both associated with
cardiovascular disease. Objective: The aim of this study was to explore the hypothesis that …

The intestinal milieu is astonishingly complex and home to a constantly changing mixture of
small and large molecules, along with an abundance of bacteria, viral particles, and …

▪ Abstract Mammalian reproduction depends on the coordinated expression of behavior with
precisely timed physiological events that are fundamentally different in males and females …

Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated
action of numerous transcription factors and associated coregulators. Several members of …

The original concept of the critical period of thyroid hormone (TH) action on brain
development was proposed to identify the postnatal period during which TH supplement …