From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

CL Wainwright, MM Teixeira, DL Adelson… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

Scorpion venom: detriments and benefits

S Ahmadi, JM Knerr, L Argemi, KCF Bordon, MB Pucca… - Biomedicines, 2020 - mdpi.com
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …

Safety and pharmacodynamics of dalazatide, a Kv1. 3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trial

EJ Tarcha, CM Olsen, P Probst, D Peckham… - PloS one, 2017 - journals.plos.org
Background Dalazatide is a specific inhibitor of the Kv1. 3 potassium channel. The
expression and function of Kv1. 3 channels are required for the function of chronically …

Unlocking the health potential of microalgae as sustainable sources of bioactive compounds

A Saide, KA Martínez, A Ianora, C Lauritano - International Journal of …, 2021 - mdpi.com
Microalgae are known to produce a plethora of compounds derived from the primary and
secondary metabolism. Different studies have shown that these compounds may have …

Kv1. 3 channel as a key therapeutic target for neuroinflammatory diseases: state of the art and beyond

X Wang, G Li, J Guo, Z Zhang, S Zhang, Y Zhu… - Frontiers in …, 2020 - frontiersin.org
It remains a challenge for the effective treatment of neuroinflammatory disease, including
multiple sclerosis (MS), stroke, epilepsy, and Alzheimer's and Parkinson's disease. The …

Phytoplankton toxins and their potential therapeutic applications: a journey toward the quest for potent pharmaceuticals

B Pradhan, JS Ki - Marine Drugs, 2022 - mdpi.com
Phytoplankton are prominent organisms that contain numerous bioactive substances and
secondary metabolites, including toxins, which can be valuable to pharmaceutical …

Biotechnological and pharmacological applications of biotoxins and other bioactive molecules from dinoflagellates

J Assunção, AC Guedes, FX Malcata - Marine Drugs, 2017 - mdpi.com
The long-lasting interest in bioactive molecules (namely toxins) produced by (microalga)
dinoflagellates has risen in recent years. Exhibiting wide diversity and complexity, said …

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Š Gubič, LA Hendrickx, Ž Toplak… - Medicinal research …, 2021 - Wiley Online Library
Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …

Scorpion species of medical importance in the Brazilian Amazon: a review to identify knowledge gaps

JG Martins, GC Santos, REL Procópio… - Journal of Venomous …, 2021 - SciELO Brasil
Scorpionism is a relevant medical condition in Brazil. It is responsible for most accidents
involving venomous animals in the country, which leads to severe symptoms that can evolve …