[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease

SM Neuner, M Telpoukhovskaia, V Menon… - Trends in …, 2022 - cell.com
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …

[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease

MI Gabitto, KJ Travaglini, VM Rachleff, ES Kaplan… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …

PT Nelson, C Brayne, ME Flanagan, EL Abner… - Acta …, 2022 - Springer
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …

LATE-NC staging in routine neuropathologic diagnosis: an update

PT Nelson, EB Lee, MD Cykowski, I Alafuzoff… - Acta …, 2023 - Springer
An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …

Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer's disease

JB Pereira, S Janelidze, R Ossenkoppele… - Brain, 2021 - academic.oup.com
It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic
function and axonal structure over the course of Alzheimer's disease. Here, we assessed …

TDP-43 pathology is associated with increased tau burdens and seeding

SO Tomé, G Tsaka, A Ronisz, S Ospitalieri… - Molecular …, 2023 - Springer
Abstract Background Most Alzheimer's Disease (AD) cases also exhibit limbic predominant
age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides …

The central role of tau in Alzheimer's disease: From neurofibrillary tangle maturation to the induction of cell death

DR Thal, SO Tomé - Brain Research Bulletin, 2022 - Elsevier
The tau protein (τ) is one of the two hallmark proteins of Alzheimer's disease (AD) together
with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …

Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change

P Scaduto, JC Lauterborn, CD Cox, A Fracassi… - Acta …, 2023 - Springer
Individuals at distinct stages of Alzheimer's disease (AD) show abnormal
electroencephalographic activity, which has been linked to network hyperexcitability and …

Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes

SO Tomé, R Vandenberghe, S Ospitalieri… - Acta Neuropathologica …, 2020 - Springer
The co-existence of multiple pathologies and proteins is a common feature in the brains of
cognitively impaired elderly individuals. Transactive response DNA-binding protein (TDP …