Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)- associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE- NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
An international consensus report in 2019 recommended a classification system for limbic- predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic function and axonal structure over the course of Alzheimer's disease. Here, we assessed …
DR Thal, SO Tomé - Brain Research Bulletin, 2022 - Elsevier
The tau protein (τ) is one of the two hallmark proteins of Alzheimer's disease (AD) together with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …
Individuals at distinct stages of Alzheimer's disease (AD) show abnormal electroencephalographic activity, which has been linked to network hyperexcitability and …
SO Tomé, R Vandenberghe, S Ospitalieri… - Acta Neuropathologica …, 2020 - Springer
The co-existence of multiple pathologies and proteins is a common feature in the brains of cognitively impaired elderly individuals. Transactive response DNA-binding protein (TDP …