Intraoperative label‐free photoacoustic histopathology of clinical specimens

JW Baik, H Kim, M Son, J Choi, KG Kim… - Laser & Photonics …, 2021 - Wiley Online Library
During cancer resection surgeries, intraoperative histopathologic examination of the surgical
specimen is crucial for tumor margin identification. A conventional frozen‐section analysis …

Imaging approaches for monitoring three‐dimensional cell and tissue culture systems

G Hilzenrat, ET Gill, SL McArthur - Journal of Biophotonics, 2022 - Wiley Online Library
The past decade has seen an increasing demand for more complex, reproducible and
physiologically relevant tissue cultures that can mimic the structural and biological features …

Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

MT Martell, NJM Haven, BD Cikaluk, BS Restall… - Nature …, 2023 - nature.com
The goal of oncologic surgeries is complete tumor resection, yet positive margins are
frequently found postoperatively using gold standard H&E-stained histology methods …

Label-free complete absorption microscopy using second generation photoacoustic remote sensing

BR Ecclestone, K Bell, S Sparkes, D Dinakaran… - Scientific Reports, 2022 - nature.com
In the past decades, absorption modalities have emerged as powerful tools for label-free
functional and structural imaging of cells and tissues. Many biomolecules present unique …

Photon absorption remote sensing imaging of breast needle core biopsies is diagnostically equivalent to gold standard H&E histologic assessment

JED Tweel, BR Ecclestone, H Gaouda, D Dinakaran… - Current …, 2023 - mdpi.com
Photon absorption remote sensing (PARS) is a new laser-based microscope technique that
permits cellular-level resolution of unstained fresh, frozen, and fixed tissues. Our objective …

[HTML][HTML] Dual-wavelength UV-visible metalens for multispectral photoacoustic microscopy: A simulation study

A Barulin, H Park, B Park, I Kim - Photoacoustics, 2023 - Elsevier
Photoacoustic microscopy is advancing with research on utilizing ultraviolet and visible light.
Dual-wavelength approaches are sought for observing DNA/RNA-and vascular-related …

Virtual hematoxylin and eosin histopathology using simultaneous photoacoustic remote sensing and scattering microscopy

BS Restall, NJM Haven, P Kedarisetti, MT Martell… - Optics …, 2021 - opg.optica.org
Hematoxylin and eosin (H&E) staining is the gold standard for most histopathological
diagnostics but requires lengthy processing times not suitable for point-of-care diagnosis …

Single acquisition label-free histology-like imaging with dual-contrast photoacoustic remote sensing microscopy

B Ecclestone, D Dinakaran… - Journal of Biomedical …, 2021 - spiedigitallibrary.org
Significance: Histopathological analysis of tissues is an essential tool for grading, staging,
diagnosing, and resecting cancers and other malignancies. Current histopathological …

Automated whole slide imaging for label-free histology using photon absorption remote sensing microscopy

JED Tweel, BR Ecclestone, M Boktor… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
Objective: Pathologists rely on histochemical stains to impart contrast in thin translucent
tissue samples, revealing tissue features necessary for identifying pathological conditions …

Investigating mechanisms of laser pulse-induced reflectivity modulations in photoacoustic remote sensing with a 10 million frames-per-second camera

NJM Haven, MT Martell, H Li, JD Hogan, RJ Zemp - Scientific Reports, 2023 - nature.com
Photoacoustic remote sensing has been recently developed as an all-optical imaging
modality capable of imaging a variety of endogenous contrast agents label-free. Initially …