Abnormal expression of mitochondrial ribosomal proteins and their encoding genes with cell apoptosis and diseases

G Huang, H Li, H Zhang - International journal of molecular sciences, 2020 - mdpi.com
Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes,
all of which play roles in the mitochondrial respiratory chain. After a long period of …

Current status of human papillomavirus-related head and neck cancer: from viral genome to patient care

H Dong, X Shu, Q Xu, C Zhu, AM Kaufmann, ZM Zheng… - Virologica Sinica, 2021 - Springer
Human papillomavirus (HPV) infection identified as a definitive human carcinogen is
increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38 …

Alternative splicing, epigenetic modifications and cancer: a dangerous triangle, or a hopeful one?

F Gimeno-Valiente, G López-Rodas, J Castillo… - Cancers, 2022 - mdpi.com
Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

High risk-human papillomavirus in HNSCC: Present and future challenges for epigenetic therapies

L Ghiani, S Chiocca - International Journal of Molecular Sciences, 2022 - mdpi.com
Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous group of
tumors characterized by an incidence of 650,000 new cases and 350,000 deaths per year …

Synergistic therapy for cervical cancer by codelivery of cisplatin and JQ1 inhibiting Plk1-mutant Trp53 axis

Y Wang, N Shen, S Li, H Yu, Y Wang, Z Liu, L Han… - Nano Letters, 2021 - ACS Publications
JQ1, a specific inhibitor of bromodomain-containing protein 4 (BRD4), could have great
potential in the treatment of cervical cancer. However, its clinical application is limited by its …

A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal

JR Qualliotine, T Nakagawa, SB Rosenthal, S Sadat… - Cancers, 2023 - mdpi.com
Simple Summary In this manuscript, we demonstrated a particular chemokine axis
(CXCR3/CXCL9, 10, 11) to be highly expressed in HPV-associated oropharynx carcinoma …

Histone marks-dependent effect on alternative splicing: new perspectives for targeted splicing modulation in cancer?

C Imbriano, S Belluti - International Journal of Molecular Sciences, 2022 - mdpi.com
Alternative splicing (AS) is a tightly regulated mechanism that generates the complex human
proteome from a small number of genes. Cis-regulatory RNA motifs in exons and introns …

Long intergenic non-coding RNAs in HNSCC: from “Junk DNA” to important prognostic factor

J Kozłowska, T Kolenda, P Poter, J Sobocińska… - Cancers, 2021 - mdpi.com
Simple Summary Head and neck squamous cell carcinoma (HNSCC) has one of the highest
incidence and mortality rates among all cancers. Diagnostic process and treatment results …

Exploring the Molecular Pathogenesis, Pathogen Association, and Therapeutic Strategies against HPV Infection

AG Mukherjee, UR Wanjari, AV Gopalakrishnan… - Pathogens, 2022 - mdpi.com
The human papillomavirus (HPV), commonly documented as the cause of warts, has gained
much interest recently due to its possible links to several types of cancer. HPV infection is …

Epigenetic regulations of perineural invasion in head and neck squamous cell carcinoma

P Hurník, Z Chyra, T Ševčíková, J Štembírek… - Frontiers in …, 2022 - frontiersin.org
Carcinomas of the oral cavity and oropharynx belong among the ten most common
malignancies in the human population. The prognosis of head and neck squamous cell …