Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models
S Caddeo, M Boffito, S Sartori - Frontiers in bioengineering and …, 2017 - frontiersin.org
In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …
Advances and Current Challenges in Intestinal in vitro Model Engineering: A Digest
J Costa, A Ahluwalia - Frontiers in bioengineering and biotechnology, 2019 - frontiersin.org
The physiological environment of the intestine is characterized by its variegated
composition, numerous functions and unique dynamic conditions, making it challenging to …
composition, numerous functions and unique dynamic conditions, making it challenging to …
3D printing of personalized thick and perfusable cardiac patches and hearts
N Noor, A Shapira, R Edri, I Gal, L Wertheim… - Advanced …, 2019 - Wiley Online Library
Generation of thick vascularized tissues that fully match the patient still remains an unmet
challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick …
challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick …
A liver-on-a-chip platform with bioprinted hepatic spheroids
The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity in
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
[HTML][HTML] A robust longitudinal co-culture of obligate anaerobic gut microbiome with human intestinal epithelium in an anoxic-oxic interface-on-a-chip
The majority of human gut microbiome comprises obligate anaerobic bacteria that exert
essential metabolic functions in the human colon. These anaerobic gut microbiomes …
essential metabolic functions in the human colon. These anaerobic gut microbiomes …
Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids
Spheroid-based three-dimensional (3D) liver culture models, offering a desirable biomimetic
microenvironment, are useful for recapitulating liver functions in vitro. However, a user …
microenvironment, are useful for recapitulating liver functions in vitro. However, a user …
Millifluidic culture improves human midbrain organoid vitality and differentiation
Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for
studying the pathogenesis of Parkinson's disease (PD). In hMOs, neuroepithelial stem cells …
studying the pathogenesis of Parkinson's disease (PD). In hMOs, neuroepithelial stem cells …
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips
In vitro models of human organs must accurately reconstitute oxygen concentrations and
gradients that are observed in vivo to mimic gene expression, metabolism, and host …
gradients that are observed in vivo to mimic gene expression, metabolism, and host …
Direct on-chip differentiation of intestinal tubules from induced pluripotent stem cells
E Naumovska, G Aalderink, C Wong Valencia… - International journal of …, 2020 - mdpi.com
Intestinal organoids have emerged as the new paradigm for modelling the healthy and
diseased intestine with patient-relevant properties. In this study, we show directed …
diseased intestine with patient-relevant properties. In this study, we show directed …
Post‐maturation reinforcement of 3D‐printed vascularized cardiac tissues
E Silberman, H Oved, M Namestnikov… - Advanced …, 2023 - Wiley Online Library
Despite advances in biomaterials engineering, a large gap remains between the weak
mechanical properties that can be achieved with natural materials and the strength of …
mechanical properties that can be achieved with natural materials and the strength of …