C-Glycopyranosyl aldehydes: emerging chiral synthons in organic synthesis

S Kumar, V Khatri, P Mangla, RJ Chhatwal… - RSC …, 2023 - pubs.rsc.org
Herein, we have summarized the vast array of synthetic processes that have been
developed for the synthesis of C-glycopyranosyl aldehydes and diverse C-glycoconjugates …

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

D Goyard, B Kónya, AS Chajistamatiou… - European Journal of …, 2016 - Elsevier
Glycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context
of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into …

Synthetic applications of hypophosphite derivatives in reduction

C Guyon, E Métay, F Popowycz… - Organic & Biomolecular …, 2015 - pubs.rsc.org
The development of new tools for the reduction of organic functions to reach high chemo-
and stereo-selectivity is an important research domain. Although, aluminum and boron …

[HTML][HTML] Glucose derived inhibitors of glycogen phosphorylase

L Somsak - Comptes Rendus Chimie, 2011 - Elsevier
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1, 3-Dipolar cycloaddition reactions on carbohydrate-based templates: synthesis of spiro-isoxazolines and 1, 2, 4-oxadiazoles as glycogen phosphorylase inhibitors

M Benltifa, S Vidal, D Gueyrard, PG Goekjian… - Tetrahedron letters, 2006 - Elsevier
1, 3-Dipolar cycloaddition of aryl nitrile oxides to benzyl/acetyl-protected exo-glucals and to
a benzoylated glucosyl cyanide led in high yield to spiro-isoxazolines and to 3-aryl-5 …

Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors

M Benltifa, JM Hayes, S Vidal, D Gueyrard… - Bioorganic & medicinal …, 2009 - Elsevier
A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio-and
stereoselective [3+ 2]-cycloaddition between the methylene acetylated exo-glucal and …

Systematic study on free radical hydrothiolation of unsaturated monosaccharide derivatives with exo-and endocyclic double bonds

L Lázár, M Csávás, Á Hadházi, M Herczeg… - Organic & …, 2013 - pubs.rsc.org
Exo-and endocyclic double bonds of glycals and terminal double bonds of enoses were
reacted with various thiols by irradiation with UV light in the presence of a cleavable …

Stereoselective Synthesis of Ribofuranoid exo-Glycals by One-Pot Julia Olefination Using Ribofuranosyl Sulfones

N Oka, A Mori, K Suzuki, K Ando - The Journal of Organic …, 2020 - ACS Publications
One-pot Julia olefination using ribofuranosyl sulfones is described. The α-anomers of the
ribofuranosyl sulfones were synthesized with complete α-selectivity via the glycosylation of …

Thio-click approach to the synthesis of stable glycomimetics

L Lázár, M Csávás, M Tóth, L Somsák, A Borbás - Chemical Papers, 2015 - degruyter.com
Carbon-sulfur-bridged glycomimetics were prepared by free radical hydrothiolation of the
exocyclic double bond of unsaturated sugars. Reaction between benzoyl-substituted …

Coupling of N‐Tosylhydrazones with Tetrazoles: A Regioselective Synthesis of 2,5‐Disubstituted‐2H‐Tetrazoles

T Kaszás, B Szakács, É Juhász‐Tóth… - European Journal of …, 2022 - Wiley Online Library
Herein we describe the C− N coupling reaction of N‐tosylhydrazones with tetrazoles using
thermic activation in the presence of different bases. The reactions proved to be highly …