Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

The advantages and challenges of using endolysins in a clinical setting

E Murray, LA Draper, RP Ross, C Hill - Viruses, 2021 - mdpi.com
Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional
antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes …

Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

Endolysin, a promising solution against antimicrobial resistance

M Rahman, W Wang, Q Sun, JA Shah, C Li, Y Sun, Y Li… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

Bacteriophage endolysins as novel antimicrobials

M Schmelcher, DM Donovan, MJ Loessner - Future microbiology, 2012 - Taylor & Francis
Endolysins are enzymes used by bacteriophages at the end of their replication cycle to
degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release …

[HTML][HTML] Alternatives to overcoming bacterial resistances: State-of-the-art

AC Rios, CG Moutinho, FC Pinto, FS Del Fiol… - Microbiological …, 2016 - Elsevier
Worldwide, bacterial resistance to chemical antibiotics has reached such a high level that
endangers public health. Presently, the adoption of alternative strategies that promote the …

Unveiling the impact of antibiotics and alternative methods for animal husbandry: A review

CX Low, LTH Tan, NS Ab Mutalib, P Pusparajah… - Antibiotics, 2021 - mdpi.com
Since the 1950s, antibiotics have been used in the field of animal husbandry for growth
promotion, therapy and disease prophylaxis. It is estimated that up to 80% of the antibiotics …

Treating bacterial infections with bacteriophage-based enzybiotics: in vitro, in vivo and clinical application

KM Danis-Wlodarczyk, DJ Wozniak, ST Abedon - Antibiotics, 2021 - mdpi.com
Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Recombinant endolysins as potential therapeutics against antibiotic-resistant Staphylococcus aureus: current status of research and novel delivery strategies

H Haddad Kashani, M Schmelcher… - Clinical microbiology …, 2018 - Am Soc Microbiol
Staphylococcus aureus is one of the most common pathogens of humans and animals,
where it frequently colonizes skin and mucosal membranes. It is of major clinical importance …