Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called
microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …

An understanding of the mechanisms that explain the initiation and early evolution of
colorectal cancer should facilitate the development of new approaches to effective …

Poulogiannis G, Frayling IM & Arends MJ (2010) Histopathology56, 167–179 DNA mismatch
repair deficiency in sporadic colorectal cancer and Lynch syndrome DNA mismatch repair …

Colorectal cancer (CRC) ranks among the three most common cancers in terms of both
cancer incidence and cancer‐related deaths in most Western countries. Serrated …

Microsatellite instability (MSI) analysis of colorectal cancers is clinically useful to identify
patients with hereditary nonpolyposis colorectal cancer (HNPCC) caused by germline …

Determining whether a tumor exhibits microsatellite instability (MSI) is useful in identifying
patients with hereditary non‐polyposis colorectal cancer and sporadic gastrointestinal …

Until recently, two major forms of colorectal epithelial polyp were recognized: the adenoma
and the hyperplastic polyp. Adenomas were perceived to represent the precursor to …