Methylation is a well‐known structural modification in organic and medicinal chemistry. This
review summarizes recent advances in methylation by categorizing specific methylation …

In the light of the recent potentials of deuterated molecules as pharmaceuticals or even in
mechanistic understanding, efficient methods for their synthesis are continually desired …

The mechanochemical, solvent‐free, highly regioselective, rhodium‐catalyzed C− H
methylation of (hetero) arenes is reported. The reaction shows excellent functional‐group …

Methylation of organohalides represents a valuable transformation, but typically requires
harsh reaction conditions or reagents. We report a radical approach for the methylation of …

In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is
gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic …

We report a dual-tasked methylation that is based on cooperative palladium/norbornene
catalysis. Readily available (hetero) aryl halides (39 iodides and 4 bromides) and …

Trifluoromethylative difunctionalization and hydrofunctionalization of unactivated alkenes
have been developed into powerful synthetic methodologies. On the other hand, methylative …

A methyl group can have a profound impact on the pharmacological properties of organic
molecules. Hence, developing methylation methods and methylating reagents is essential in …

Methylation is one of the most fundamental conversions in medicinal and material chemistry.
Extension of substrate types from aromatic halides to other unconventional aromatic …

Five membered N‐heterocycles are significant targets in organic synthesis because of their
ubiquitous existence in bioactive natural products and pharmaceuticals. Over the past …