Summary 25% of all people aged 55 years and older have a family history of dementia. For
most, the family history is due to genetically complex disease, where many genetic …

Pathophysiology of the neurovascular unit (NVU) is commonly seen in neurological
diseases. The typical features of NVU pathophysiology include tissue hypoxia, inflammatory …

Objective Cerebral small vessel diseases (cSVDs) are a major cause of stroke and
dementia. We used cutting‐edge 7T‐MRI techniques in patients with Cerebral Autosomal …

Astrocytes express laminin and assemble basement membranes (BMs) at their endfeet,
which ensheath the cerebrovasculature. The function of astrocytic laminin in …

Cerebral small vessel disease is considered hereditary in about 5% of patients and is
characterized by lacunar infarcts and white matter hyperintensities on MRI. Several …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leucoencephalopathy (CADASIL) is an autosomal dominant vascular disorder. Diagnosis …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a …

Dementia is a syndrome characterised by a decline in cognitive abilities, such as memory,
thinking, and reasoning, that is severe enough to interfere with daily functioning. It is not a …

Modern imaging methods provide unprecedented insights into brain structure, perfusion,
metabolism, and neurochemistry, both during and between migraine attacks. Neuroimaging …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is an inherited small artery disease caused by NOTCH3 …