T follicular helper cells in autoimmune disorders
T follicular helper (Tfh) cells are a distinct subset of CD4+ T lymphocytes, specialized in B
cell help and in regulation of antibody responses. They are required for the generation of …
cell help and in regulation of antibody responses. They are required for the generation of …
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in
diagnosis for decades. However, the immunological mechanism underlying their generation …
diagnosis for decades. However, the immunological mechanism underlying their generation …
T cell/B cell collaboration and autoimmunity: an intimate relationship
L Petersone, NM Edner, V Ovcinnikovs… - Frontiers in …, 2018 - frontiersin.org
Co-ordinated interaction between distinct cell types is a hallmark of successful immune
function. A striking example of this is the carefully orchestrated cooperation between helper …
function. A striking example of this is the carefully orchestrated cooperation between helper …
Regulators of Tfh cell differentiation
The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class
switching, and germinal center (GC) formation. The Tfh cells are characterized by the …
switching, and germinal center (GC) formation. The Tfh cells are characterized by the …
Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice
JJ Dolence, T Kobayashi, K Iijima, J Krempski… - Journal of Allergy and …, 2018 - Elsevier
Background Little is currently known regarding the immunologic mechanism (s) that initiate
peanut allergy. Notably, peanut proteins have been detected in house dust, and their levels …
peanut allergy. Notably, peanut proteins have been detected in house dust, and their levels …
Two populations of circulating PD-1hiCD4 T cells with distinct B cell helping capacity are elevated in early rheumatoid arthritis
P Fortea-Gordo, L Nuño, A Villalba, D Peiteado… - …, 2019 - academic.oup.com
Objective A novel population of B helper cells, phenotypically CD4+ CXCR5− PD-1hi, has
been described in the synovial tissues and peripheral blood of seropositive RA patients, and …
been described in the synovial tissues and peripheral blood of seropositive RA patients, and …
T cell specific Cxcr5 deficiency prevents rheumatoid arthritis
GL Moschovakis, A Bubke, M Friedrichsen, CS Falk… - Scientific reports, 2017 - nature.com
The chemokine receptor CXCR5 is primarily expressed on B cells and Tfh cells and
facilitates their migration towards B cell follicles. In the present study we investigated the role …
facilitates their migration towards B cell follicles. In the present study we investigated the role …
Synaptic interactions in germinal centers
I Papa, CG Vinuesa - Frontiers in immunology, 2018 - frontiersin.org
The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows
the generation of high-affinity antibody-producing plasma cells and memory B cells. These …
the generation of high-affinity antibody-producing plasma cells and memory B cells. These …
TANK-binding kinase 1-dependent responses in health and autoimmunity
The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic
lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers …
lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers …
SLAM associated protein signaling in T cells: tilting the balance toward autoimmunity
Y Gartshteyn, AD Askanase, A Mor - Frontiers in Immunology, 2021 - frontiersin.org
T cell activation is the result of the integration of signals across the T cell receptor and
adjacent co-receptors. The signaling lymphocyte activation molecules (SLAM) family are …
adjacent co-receptors. The signaling lymphocyte activation molecules (SLAM) family are …