Interneurons from embryonic development to cell-based therapy
DG Southwell, CR Nicholas, AI Basbaum, MP Stryker… - Science, 2014 - science.org
Background Alterations in neural excitation and inhibition cause a number of neurologic and
psychiatric disorders. In the cerebral cortex, excitation and inhibition are mediated by two …
psychiatric disorders. In the cerebral cortex, excitation and inhibition are mediated by two …
Genomic perspectives of transcriptional regulation in forebrain development
The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric
disorders are due to genetic defects affecting forebrain development, making it imperative to …
disorders are due to genetic defects affecting forebrain development, making it imperative to …
A viral strategy for targeting and manipulating interneurons across vertebrate species
A fundamental impediment to understanding the brain is the availability of inexpensive and
robust methods for targeting and manipulating specific neuronal populations. The need to …
robust methods for targeting and manipulating specific neuronal populations. The need to …
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients
Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious
mutations in SCN1A, the gene encoding neuronal sodium channel Nav1. 1. Earlier studies …
mutations in SCN1A, the gene encoding neuronal sodium channel Nav1. 1. Earlier studies …
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position
Cortical GABAergic interneurons have essential roles for information processing and their
dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating …
dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating …
GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges
Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons
and their axon terminals, and/or alterations in functional inhibition are conspicuous brain …
and their axon terminals, and/or alterations in functional inhibition are conspicuous brain …
Human pluripotent stem cell–derived models and drug screening in CNS precision medicine
MC Silva, SJ Haggarty - Annals of the New York Academy of …, 2020 - Wiley Online Library
Abstract Development of effective therapeutics for neurological disorders has historically
been challenging partly because of lack of accurate model systems in which to investigate …
been challenging partly because of lack of accurate model systems in which to investigate …
GABAergic interneuron transplants to study development and treat disease
JA Tyson, SA Anderson - Trends in neurosciences, 2014 - cell.com
Advances in stem cell technology have engendered keen interest in cell-based therapies for
neurological disorders. Postnatal engraftments of most neuronal precursors result in little …
neurological disorders. Postnatal engraftments of most neuronal precursors result in little …
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the
mechanism generating their diversity remains elusive. We performed single-cell RNA …
mechanism generating their diversity remains elusive. We performed single-cell RNA …
Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer׳ s and Parkinson׳ s diseases
AK Shetty, A Bates - Brain research, 2016 - Elsevier
Several neurological and psychiatric disorders present hyperexcitability of neurons in
specific regions of the brain or spinal cord, partly because of some loss and/or dysfunction of …
specific regions of the brain or spinal cord, partly because of some loss and/or dysfunction of …