[HTML][HTML] A comprehensive review on phage therapy and phage-based drug development

L Cui, S Watanabe, K Miyanaga, K Kiga, T Sasahara… - Antibiotics, 2024 - mdpi.com
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining
momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) …

Fitness trade-offs between phage and antibiotic sensitivity in phage-resistant variants: molecular action and insights into clinical applications for phage therapy

J Fujiki, K Nakamura, T Nakamura, H Iwano - International Journal of …, 2023 - mdpi.com
In recent decades, phage therapy has been overshadowed by the widespread use of
antibiotics in Western countries. However, it has been revitalized as a powerful approach …

Bacteriophages in nature: recent advances in research tools and diverse environmental and biotechnological applications

M Bisen, K Kharga, S Mehta, N Jabi… - Environmental Science and …, 2024 - Springer
Bacteriophages infect and replicate within bacteria and play a key role in the environment,
particularly in microbial ecosystems and bacterial population dynamics. The increasing …

Physiochemical characterization of a potential Klebsiella phage MKP-1 and analysis of its application in reducing biofilm formation

S Das, S Kaledhonkar - Frontiers in Microbiology, 2024 - frontiersin.org
The common intestinal pathogen Klebsiella pneumoniae (K. pneumoniae) is one of the
leading causes of fatal superbug infections that can resist the effects of commonly …

Synergistic action of phages and lytic proteins with antibiotics: a combination strategy to target bacteria and biofilms

H Lu, Z Li, A Elbaz, SQ Ni - BMC microbiology, 2023 - Springer
Background Multidrug-resistant bacteria continue to emerge owing to the abuse of
antibiotics and have a considerable negative impact on people and the environment …

Characterization of ES10 lytic bacteriophage isolated from hospital waste against multidrug-resistant uropathogenic E. coli

A Nawaz, S Zafar, AH Alessa, NA Khalid… - Frontiers in …, 2024 - frontiersin.org
Escherichia coli is the major causative agent of urinary tract infections worldwide and the
emergence of multi-drug resistant determinants among clinical isolates necessitates the …

Genomic and biological insights of bacteriophages JNUWH1 and JNUWD in the arms race against bacterial resistance

H Zhang, J You, X Pan, Y Hu, Z Zhang… - Frontiers in …, 2024 - frontiersin.org
The coevolution of bacteria and bacteriophages has created a great diversity of mechanisms
by which bacteria fight phage infection, and an equivalent diversity of mechanisms by which …

Biological characteristics of the bacteriophage LDT325 and its potential application against the plant pathogen Pseudomonas syringae

L Liu, B Wang, A Huang, H Zhang, Y Li… - Frontiers in …, 2024 - frontiersin.org
Bud blight disease caused by Pseudomonas syringae is a major bacterial disease of tea
plants in China. Concerns regarding the emergence of bacterial resistance to conventional …

[HTML][HTML] Advancing Phage Therapy: A Comprehensive Review of the Safety, Efficacy, and Future Prospects for the Targeted Treatment of Bacterial Infections

M Palma, B Qi - Infectious Disease Reports, 2024 - pmc.ncbi.nlm.nih.gov
Background: Phage therapy, a treatment utilizing bacteriophages to combat bacterial
infections, is gaining attention as a promising alternative to antibiotics, particularly for …

Isolation and characterization of bacteriophages against E. coli urinary tract infection and evaluating their anti-biofilm activity and antibiotic synergy

KV Leela, S Sugumar - Microbial Pathogenesis, 2024 - Elsevier
Urinary tract infections (UTIs) by Uropathogenic Escherichia coli (UPEC) are a significant
health concern, especially due to the increasing prevalence of antibiotic resistance. This …