Transient receptor potential (TRP) proteins form a superfamily of cation channels that are
expressed in a wide range of tissues and cell types. During the last years, great progress …

The overload cytosolic free Ca2+ (cCa2+) influx-mediated excessive generation of oxidative
stress in the pathophysiological conditions induces neuronal and cellular injury via the …

Sepsis is a common critical illness in ICU and always a great difficulty in clinical treatment.
GPR43 (G protein-coupled receptor 43) participates in regulating appetite and …

Gastrointestinal cancer may be associated with dysbiosis, which is characterized by an
alteration of the gut microbiota. Understanding the role of gut microbiota in the development …

With the increase in alcohol consumption, more and more people are suffering from
alcoholic liver disease (ALD). Therefore, it is necessary to elaborate the pathogenesis of …

It is well known that alcohol consumption leads to substantially increased free radical levels
and health risks, which lacks effective treatment besides alcohol abstinence. Here, we …

This study explored the role of transient receptor potential channel melastatin 2 (TRPM2)-
mediated activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) …

This study aimed to examine whether the administration of losartan can prevent acute
elevation of pulmonary arterial pressure (AEPAP) induced by endovascular ethanol injection …

Spinal cord injury (SCI) is a devastating neurological disorder that often results in loss of
motor and sensory function. Diabetes facilitates the blood-spinal cord barrier (BSCB) …

Glia are essential neurons of the immune system in the central nervous system. The effective
mission of glia depends on their activation, release of cytokines, and oxidative cleaning of …