Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

Myeloid immune cells are frequently present in the tumor environment, and although they
can positively contribute to tumor control they often negatively impact anticancer immune …

CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα,
which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat …

Timely removal of dying or pathogenic cells by phagocytes is essential to maintaining host
homeostasis. Phagocytes execute the clearance process with high fidelity while sparing …

A numerous number of positive and negative signals via various molecules modulate T-cell
activation. Within the various transmembrane proteins, SIRPγ is of interest since it is not …

Macrophages are essential mediators of innate immunity. Non-self-cells resist phagocytosis
through the expression of the checkpoint molecule CD47. CD47, as the integrin-associated …

The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan,
China, has become a worldwide pandemic affecting almost 204 million people and causing …

Immunotherapy has revolutionized the modality for establishing a firm immune response
and immunological memory. However, intrinsic limitations of conventional low responsive …

Porphyromonas gingivalis is a gram-negative anaerobic bacterium linked to periodontal
disease. Remarkably, P. gingivalis thrives in an inflamed environment rich in activated …