Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Amoeboid microglial cells (AMCs) in the developing brain display surface receptors and
antigens shared by the monocyte-derived tissue macrophages. Activation of AMCs in the …

Autophagy, an intracellular bulk degradation process of cellular constituents, plays a key
role in cell homeostasis and can be induced by stresses, such as nutrient depletion, closed …

We have previously shown that in neonatal rats subjected to hypoxia-ischemia (HI)
rapamycin administration increases autophagy, decreases apoptosis and significantly …

Perinatal brain injury is the leading cause of neurological mortality and morbidity in
childhood ranging from motor and cognitive impairment to behavioural and neuropsychiatric …

Hypoxic injury in the perinatal period results in periventricular white matter (PWM) lesions
with axonal damage and oligodendroglial loss. It also alters macrophage function by …

The schizophrenia research community, including government, industry, and academia, has
made development of procognitive treatment strategies a priority. Much current research is …

Backgroud Cerebral vasospasm (CVS) and early brain injury remain major causes of
morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH) …

Periventricular white matter damage (PWMD) also known as periventricular white matter
injury, is one of the major causes of neurological impairment in premature newborns. The …

The developing cerebellum is extremely vulnerable to hypoxia which can damage the
Purkinje neurons. We hypothesized that this might be mediated by tumor necrosis factor-α …