Innate immune evasion strategies of SARS-CoV-2

JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

Machinery, regulation and pathophysiological implications of autophagosome maturation

YG Zhao, P Codogno, H Zhang - Nature Reviews Molecular Cell …, 2021 - nature.com
Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

S Klein, M Cortese, SL Winter… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
COVID19 pandemic, is a highly pathogenic β-coronavirus. As other coronaviruses, SARS …

Cryo-electron tomography on focused ion beam lamellae transforms structural cell biology

C Berger, N Premaraj, RBG Ravelli, K Knoops… - Nature …, 2023 - nature.com
Cryogenic electron microscopy and data processing enable the determination of structures
of isolated macromolecules to near-atomic resolution. However, these data do not provide …

How the coronavirus infects cells—and why Delta is so dangerous

M Scudellari - 2021 - covid19.sld.cu
How the coronavirus infects cells — and why Delta is so dangerous Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

[HTML][HTML] ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

G Miao, H Zhao, Y Li, M Ji, Y Chen, Y Shi, Y Bi… - Developmental cell, 2021 - cell.com
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

GQ Liu, JH Lee, ZM Parker, D Acharya, JJ Chiang… - Nature …, 2021 - nature.com
Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma
differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating …