The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
K Suzuki, Y Tsunekawa, R Hernandez-Benitez, J Wu… - Nature, 2016 - nature.com
Targeted genome editing via engineered nucleases is an exciting area of biomedical
research and holds potential for clinical applications. Despite rapid advances in the field, in …
research and holds potential for clinical applications. Despite rapid advances in the field, in …
Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
Review of the current trends in clinical trials involving induced pluripotent stem cells
JY Kim, Y Nam, YA Rim, JH Ju - Stem cell reviews and reports, 2022 - Springer
In 2006, the induced pluripotent stem cell (iPSC) was presented to the world, paving the way
for the development of a magnitude of novel therapeutic alternatives, addressing a diverse …
for the development of a magnitude of novel therapeutic alternatives, addressing a diverse …
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency.
Here, we report on the generation of a human WS model in human embryonic stem cells …
Here, we report on the generation of a human WS model in human embryonic stem cells …
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
[HTML][HTML] Regulation of stem cell aging by metabolism and epigenetics
Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …
associated declines in stem cell function are characterized by metabolic and epigenetic …
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration
Accumulating evidence indicates an association between the circadian clock and the aging
process. However, it remains elusive whether the deregulation of circadian clock proteins …
process. However, it remains elusive whether the deregulation of circadian clock proteins …