Assessment of azithromycin as an anticancer agent for treatment of imatinib sensitive and resistant CML cells

T Ozkan, Y Hekmatshoar, AZ Karabay, A Koc… - Leukemia Research, 2021 - Elsevier
Abstract Introduction Chronic Myeloid Leukemia (CML) is a hematological disease which is
characterized by the presence of BCR-ABL fusion protein. Imatinib (IMA), a tyrosine kinase …

Food additive sodium benzoate (NaB) activates NFκB and induces apoptosis in HCT116 cells

B Yilmaz, AZ Karabay - Molecules, 2018 - mdpi.com
NaB, the metabolite of cinnamon and sodium salt of benzoic acid is a commonly used food
and beverage preservative. Various studies have investigated NaB for its effects on different …

Expressions of homeobox, collagen and estrogen genes in women with uterine prolapse

F Dökmeci, F Tekşen, ŞE Çetinkaya, T Özkan… - European Journal of …, 2019 - Elsevier
Objective Genetic contribution is thought to be involved in the pathophysiology of pelvic
organ prolapse (POP). We aimed to study the gene expression profiles of the genes …

Characterization of imatinib-resistant K562 cell line displaying resistance mechanisms

Y Hekmatshoar, T Özkan… - Cellular and …, 2018 - avesis.ankara.edu.tr
Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by the t (9;
22) and the related oncogene, BCR-ABL. Tyrosine kinase activity of fusion protein BCR-ABL …

Methylsulfonylmethane induces caspase‐dependent apoptosis in acute myeloid leukemia cell lines

Y Hekmatshoar, AZ Karabay, T Ozkan… - Fundamental & …, 2024 - Wiley Online Library
Background: Acute myeloid leukemia (AML) is a heterogeneous ailment in both biological
and clinical concepts. Numerous efforts have been devoted to discover natural compounds …

Exploring the active ingredients and mechanisms of Liujunzi decoction in treating hepatitis B: a study based on network pharmacology, molecular docking, and …

Q Ma, W Li, W Wu, M Sun - Computer Methods in Biomechanics …, 2024 - Taylor & Francis
Liujunzi decoction (LJZD) is commonly used to treat hepatitis B virus (HBV), though its active
ingredients and mechanisms are not fully known. This study identified core targets and …

Fluorescence labelled XT5 modified nano-capsules enable highly sensitive myeloma cells detection

AN Dizaji, MY Kohneshahri, S Gafil… - …, 2022 - iopscience.iop.org
Accurate diagnosis of cancer cells in early stages plays an important role in reliable
therapeutic strategies. In this study, we aimed to develop fluorescence-conjugated polymer …

[HTML][HTML] Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid …

Z Iqbal, M Absar, A Mahmood, A Aleem… - Asian Pacific Journal …, 2020 - ncbi.nlm.nih.gov
Objective: BCR-ABL fusion oncogene is the hallmark of chronic myeloid leukemia (CML),
causing genomic instability which leads to accumulation of mutations in BCR-ABL as well as …

[引用][C] Yeni Sentezlenen Benzamit Türevi Molekülün Toksik Etkilerinin Hayvan Modelinde Araştırılması ve Multipl Miyelomlu Farelere Uygulanması

E Turasan - 2021 - Fen Bilimleri Enstitüsü