▪ Abstract Ubiquitin regulates protein transport between membrane compartments by serving
as a sorting signal on protein cargo and by controlling the activity of trafficking machinery …

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

The activity of the c-Kit receptor protein-tyrosine kinase is tightly regulated in normal cells,
whereas deregulated c-Kit kinase activity is implicated in the pathogenesis of human …

Sphingosine kinase 1 is an agonist‐activated signalling enzyme that catalyses the formation
of sphingosine 1‐phosphate, a lipid second messenger that has been implicated in a …

Specific protein-protein interactions are involved in a large number of cellular processes and
are mainly mediated by structurally and functionally defined domains. Here we report that …

The ErbB-4 receptor protein-tyrosine kinase is proteolytically processed by membrane
proteases in response to the ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation …

WW domains are small protein modules composed of approximately 40 amino acids. These
domains fold as a stable, triple stranded β-sheet and recognize proline-containing ligands …

Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and
inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein …

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

The Hippo pathway in Drosophila controls the size and shape of organs. In the fly, activation
of this pathway conveys growth-inhibitory signals and promotes apoptosis in epithelial cells …