Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Pathological mechanism of photodynamic therapy and photothermal therapy based on nanoparticles

Y Hou, X Yang, R Liu, D Zhao, C Guo… - International journal …, 2020 - Taylor & Francis
The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy
(PTT) which generates heat and photodynamic therapy (PDT) which not only generates …

[HTML][HTML] Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development

Y Sun, D Zhao, G Wang, Y Wang, L Cao, J Sun… - … Pharmaceutica Sinica B, 2020 - Elsevier
Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the
tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable …

Conjugates of porphyrinoid-based photosensitizers with cytotoxic drugs: current progress and future directions toward selective photodynamic therapy

VF Otvagin, NS Kuzmina, ES Kudriashova… - Journal of medicinal …, 2022 - ACS Publications
Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of
photosensitizers in a patient's body leads to the generation of cytotoxic reactive oxygen …

Overview of recent strategic advances in medicinal chemistry

G Wu, T Zhao, D Kang, J Zhang, Y Song… - Journal of medicinal …, 2019 - ACS Publications
Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

Molecular targeting of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)

NEM Kaufman, S Dhingra, SD Jois, MGH Vicente - Molecules, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor
(VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins …

Surface-decorated porphyrinic zirconium-based metal–organic frameworks (MOFs) using post-synthetic self-assembly for photodegradation of methyl orange dye

AM Kobaisy, MF Elkady, AA Abdel-Moneim… - RSC …, 2023 - pubs.rsc.org
We report herein the surface decoration of a water-soluble free-base porphyrin, namely, 5,
10, 15, 20-tetrakis (1-methyl-4-pyridinio) porphyrin-tetra (p-toluenesulfonate)(H2TMPyP) …

EGFR-targeted photodynamic therapy

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - Pharmaceutics, 2022 - mdpi.com
The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and
metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are …

[HTML][HTML] Application of photoactive compounds in cancer theranostics: review on recent trends from photoactive chemistry to artificial intelligence

P Szymaszek, M Tyszka-Czochara, J Ortyl - Molecules, 2024 - mdpi.com
According to the World Health Organization (WHO) and the International Agency for
Research on Cancer (IARC), the number of cancer cases and deaths worldwide is predicted …

Recent advances in photodynamic therapy for deep-seated tumors with the aid of nanomedicine

WP Li, CJ Yen, BS Wu, TW Wong - Biomedicines, 2021 - mdpi.com
Photodynamic therapy (PDT) works through photoactivation of a specific photosensitizer
(PS) in a tumor in the presence of oxygen. PDT is widely applied in oncology to treat various …