Evolution of circadian rhythms: from bacteria to human

U Bhadra, N Thakkar, P Das, MP Bhadra - Sleep medicine, 2017 - Elsevier
The human body persists in its rhythm as per its initial time zone, and transition always occur
according to solar movements around the earth over 24 h. While traveling across different …

Temperature effect on entrainment, phase shifting, and amplitude of circadian clocks and its molecular bases

L Rensing, P Ruoff - Chronobiology international, 2002 - Taylor & Francis
Effects of temperature and temperature changes on circadian clocks in cyanobacteria,
unicellular algae, and plants, as well as fungi, arthropods, and vertebrates are reviewed …

[HTML][HTML] Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations

JR Pomerening, SY Kim, JE Ferrell - Cell, 2005 - cell.com
The cell-cycle oscillator includes an essential negative-feedback loop: Cdc2 activates the
anaphase-promoting complex (APC), which leads to cyclin destruction and Cdc2 …

Tuning the mammalian circadian clock: robust synergy of two loops

A Relógio, PO Westermark, T Wallach… - PLoS computational …, 2011 - journals.plos.org
The circadian clock is accountable for the regulation of internal rhythms in most living
organisms. It allows the anticipation of environmental changes during the day and a better …

Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana

JCW Locke, AJ Millar, MS Turner - Journal of theoretical biology, 2005 - Elsevier
Circadian clocks in all organisms include feedback loops that generate rhythmic expression
of key genes. We model the first such loop proposed for the clock of Arabidopsis thaliana …

Multilevel regulation of the circadian clock

N Cermakian, P Sassone-Corsi - Nature Reviews Molecular Cell …, 2000 - nature.com
Living organisms adapt to light–dark rhythmicity using a complex programme based on
internal clocks. These circadian clocks, which are regulated by the environment, direct …

Genetic and Molecular Analysis of Circadian Rhythms in N eurospora

JJ Loros, JC Dunlap - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract Over the course of the past 40 years Neurospora has become a well-known and
uniquely tractable model system for the analysis of the molecular basis of eukaryotic …

(Re) inventing the circadian feedback loop

SA Brown, E Kowalska, R Dallmann - Developmental cell, 2012 - cell.com
For 20 years, researchers have thought that circadian clocks are defined by feedback loops
of transcription and translation. The rediscovery of posttranslational circadian oscillators in …

The Goodwin model: behind the Hill function

D Gonze, W Abou-Jaoudé - PloS one, 2013 - journals.plos.org
The Goodwin model is a 3-variable model demonstrating the emergence of oscillations in a
delayed negative feedback-based system at the molecular level. This prototypical model …

Feedback loops of the mammalian circadian clock constitute repressilator

JP Pett, A Korenčič, F Wesener, A Kramer… - PLoS computational …, 2016 - journals.plos.org
Mammals evolved an endogenous timing system to coordinate their physiology and
behaviour to the 24h period of the solar day. While it is well accepted that circadian rhythms …