Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Microbiota and the social brain

E Sherwin, SR Bordenstein, JL Quinn, TG Dinan… - Science, 2019 - science.org
BACKGROUND Increasingly, it is recognized that the microbes resident in the
gastrointestinal tract can influence brain physiology and behavior. Research has shown that …

Systematic review of gut microbiota and major depression

SG Cheung, AR Goldenthal, AC Uhlemann… - Frontiers in …, 2019 - frontiersin.org
Background: Recently discovered relationships between the gastrointestinal microbiome
and the brain have implications for psychiatric disorders, including major depressive …

The gut microbiome in depression and potential benefit of prebiotics, probiotics and synbiotics: a systematic review of clinical trials and observational studies

SR Alli, I Gorbovskaya, JCW Liu, NJ Kolla… - International journal of …, 2022 - mdpi.com
An emerging body of literature demonstrates differences in the gut microbiome (GMB) of
patients with major depressive disorder (MDD) compared to healthy controls (HC), as well …

New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Biological, psychological, and social determinants of depression: a review of recent literature

O Remes, JF Mendes, P Templeton - Brain sciences, 2021 - mdpi.com
Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases

F Hosseinkhani, A Heinken, I Thiele… - Gut …, 2021 - Taylor & Francis
The interaction disorder between gut microbiota and its host has been documented in
different non-communicable diseases (NCDs) such as metabolic syndrome …

Recognizing depression from the microbiota–gut–brain axis

S Liang, X Wu, X Hu, T Wang, F Jin - International journal of molecular …, 2018 - mdpi.com
Major depression is one of the leading causes of disability, morbidity, and mortality
worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the …